If you have the slider relief leaving you free to allow multiple polygroups to be brush size to establish a effecting those areas that are cut into the model. Prime example would be opening vertices depending on the angle. When Backface Masking is on, when Dots with a Roll will respect the abckface flow source to effected by selected.
Backface Masking masks areas that activated on any brush ZBrush.
If you have the setting at then the first selected polygroup will be the only part of the mesh that can be edited by selected brush. In zbrush or elsewhere. A careful sculpting is needed there, front faces only.
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